Chemical Carcinogens
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Chemical Carcinogens Activation Mechanisms Structural and Electronic Factors and Reactivity (Bioactive Molecules Vol 5) by P. Politzer

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Published by Elsevier Science Ltd .
Written in English


Book details:

Edition Notes

ContributionsF. J. Martin (Editor)
The Physical Object
Number of Pages382
ID Numbers
Open LibraryOL7530320M
ISBN 100444430083
ISBN 109780444430083

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Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Seventh Edition, has proven to be a reliable, accessible, must-have reference on hazardous materials for over thirty updated and revised seventh edition is the most comprehensive listing of the hazardous chemicals commonly used, transported, and regulated in industry and the : $ Broadly, physical carcinogens includes a wide range of agents: electromagnetic radiations of different kinds, corpuscular (alpha and beta) radiations, low and high temperatures, mechanical traumas, and solid and gel materials. More restrictively, however, the term is ordinarily used to define solid and gel materials, water-insoluble or slightly soluble, that are capable of producing cancer.   Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins Book Edition: 1. Also included is a general guide to chemical resistant gloves and an extensive bibliography. The appendices include listings on oxidizing materials and carcinogens, a glossary, international hazard codes, risk phrases, safety phrases, and an extensive cross-listing index.

Key words: cancer stages,carcinogenesis evaluation, chemical carcinogens, chemical carcinogenesis. INTRODUCTION Public opinion considers cancer to be an increasingly threatening disease, affecting people of all ages. After cardiovascular diseases, it is the second cause of death amongst the global population (Huff , Weisburger. Chemical Carcinogens Some Guidelines for Handling and Disposal in the Laboratory. Authors: Castegnaro, Marcel, Sansone, Eric B. Free Preview. Buy this book eB08 € price for Spain (gross) Buy eBook ISBN ;.   This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form 2/5(2). Mutagenicity and carcinogenicity are clearly correlated. One study showed that of known carcinogens (approximately 90 percent) are also mutagens. The somatic mutation theory of cancer holds that these agents cause cancer by inducing the mutation of somatic cells. Thus, understanding mutagenesis is of great relevance to our society.

This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal cturer: Humana. Co-carcinogens, which are chemical substances that cannot induce cancer when they are administered alone, but can enhance the carcinogenic effect of other substances. In general, co-carcinogens act as promoters in tissues in which the initiation stage has appeared. Through the reticulo-endoplasmic system, the detoxification of the organism from foreign substances usually occurs by hydrolysis. Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Seventh Edition, has proven to be a reliable, accessible, must-have reference on hazardous materials for over thirty years. This updated and revised seventh edition is the most comprehensive listing of the hazardous chemicals commonly used, transported, and regulated in industry and the workplace. 1. Most chemical carcinogens are mutagens 2. Most carcinogens and mutagens are strong electrophilic reactants. 3 Ionizing or ultraviolet radiation and most chemical carcinogens cause3. Ionizing or ultraviolet radiation and most chemical carcinogens cause lesions in DNA. 4. Defects in DNA repair capacity are associated with a high risk of Size: 2MB.